Parallel Determination of Voriconazole and Posaconazole in Plasma by HPLC

Authors

  • L. Malášková Department of Clinical Biochemistry and Hematology, University Hospital, Brno
  • J. Winterová Department of Internal Medicine and Hematooncology, University Hospital, Brno
  • M. Dastych Department of Clinical Biochemistry and Hematology, University Hospital, Brno
  • Z. Ráčil Department of Internal Medicine and Hematooncology, University Hospital, Brno
  • I. Kocmanová Department of Clinical Microbiology, University Hospital, Brno
  • M. Tošková Department of Clinical Biochemistry and Hematology, University Hospital, Brno
  • J. Mayer Department of Internal Medicine and Hematooncology, University Hospital, Brno

Keywords:

HPLC, antifungal therapy, voriconazole, posaconazole

Abstract

Voriconazole and posaconazole are azole broad-spectrum pharmaceuticals used in treatment and prophylaxis of invasive fungal infections. Determination of both the antifungals in blood plasma in the course of treatment makes it possible to achieve optimal dosing. Our aim was to integrate voriconazole and posaconazole monitoring in the treatment of fungal infections in hematooncological patients. At present the simple and rapid ultra performance liquid chromatography (UPLC) monitoring of both the antifungals is a part of daily routine.

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Published

2012-07-15

How to Cite

Malášková, L., Winterová, J., Dastych, M., Ráčil, Z., Kocmanová, I., Tošková, M., & Mayer, J. (2012). Parallel Determination of Voriconazole and Posaconazole in Plasma by HPLC. Chemické Listy, 106(7), 677–680. Retrieved from http://blog.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/896

Issue

Vol. 106 No. 7 (2012)

Section

Articles

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