The MALDI Imaging for Study of the Physiological Processes in Tumors

Authors

  • R. Guráň Department of Chemistry and Biochemistry, Mendel University, Brno | Central European Institute of Technology, Brno University of Technology, Brno
  • O. Zítka Department of Chemistry and Biochemistry, Mendel University, Brno | Central European Institute of Technology, Brno University of Technology, Brno
  • M. A. M. Rodrigo Department of Chemistry and Biochemistry, Mendel University, Brno | Central European Institute of Technology, Brno University of Technology, Brno
  • V. Adam Department of Chemistry and Biochemistry, Mendel University, Brno | Central European Institute of Technology, Brno University of Technology, Brno
  • R. Kizek Department of Chemistry and Biochemistry, Mendel University, Brno | Central European Institute of Technology, Brno University of Technology, Brno

Keywords:

MALDI MSI, tumor markers, imaging methods

Abstract

In recent years, MALDI imaging mass spectrometry, also known as MALDI imaging or MALDI MSI, has been getting wider recognition thanks to an increasing number of studies devoted to various tumor markers, comparing 2D mass maps of healthy and diseased tissue sections. By determining the spatial distribution of markers in the tissue we step forward to clarify the physiological processes in tumors and to better understand them. Moreover, by combining 2D mass maps with microscopic photos of the sections from histology, we get a more comprehensive picture of the distribution of the examined analytes. However, one of the disadvantages of MALDI imaging is a complicated ionization of analytes in a complex matrix of tissues and thus low detection limits. In this paper we report on the current state of MALDI imaging in oncology research. Development option of this method in the near future is outlined according to authors' opinion.

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Published

2016-02-15

How to Cite

Guráň, R., Zítka, O., Rodrigo, M. A. M., Adam, V., & Kizek, R. (2016). The MALDI Imaging for Study of the Physiological Processes in Tumors. Chemické Listy, 110(2), 106–111. Retrieved from http://blog.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/230

Issue

Vol. 110 No. 2 (2016)

Section

Articles

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