Electrochemical Methods for the Determination of Homovanillic, Vanillylmandelic, and 5-Hydroxy-3-indoleacetic Acid as Cancer Biomarkers

Authors

  • A. Makrlíková Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague | J. Heyrovský Institute of Physical Chemistry of the AS CR, Prague
  • J. Barek Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague
  • V. Vyskočil Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Prague
  • T. Navrátil J. Heyrovský Institute of Physical Chemistry of the AS CR, Prague

Keywords:

homovanillic acid, vanillylmandelic acid, 5-hydroxy-3-indoleacetic acid, tumor biomarkers, voltammetry, amperometry, HPLC with electrochemical detection

Abstract

Homovanillic (HVA), vanillylmandelic (VMA), and 5-hydroxy-3-indoleacetic acid (HIAA) are cancer biomarkers and their abnormally high urinary levels can serve as a useful tool for prediction of neuroblastoma, pheochromocytoma, and carcinoid tumors. HVA and VMA are connected with the catecholamine metabolism, while HIAA is related to the tryptophan metabolism. The aim of this review is to describe the electrochemical oxidation HVA, VMA, and HIAA and summarize published voltammetric and amperometric methods suitable for the determination of these biomarkers in various biological fluids.

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Published

2018-09-15

How to Cite

Makrlíková, A., Barek, J., Vyskočil, V., & Navrátil, T. (2018). Electrochemical Methods for the Determination of Homovanillic, Vanillylmandelic, and 5-Hydroxy-3-indoleacetic Acid as Cancer Biomarkers. Chemické Listy, 112(9), 605–615. Retrieved from http://blog.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3176

Issue

Vol. 112 No. 9 (2018)

Section

Articles