Flow Properties of Powder Mixtures as Factors of Hard Gelatin Capsule Filling

Authors

  • P. Komínová Department of Organic Technology, University of Chemistry and Technology Prague, Prague
  • P. Zámostný Department of Organic Technology, University of Chemistry and Technology Prague, Prague

Keywords:

hard gelatin capsules, powders, rheological properties, direct filling, tamp filling machine, dosator nozzle

Abstract

Hard gelatin capsules belong to the most commonly used pharmaceutical solid dosage forms but their filling using capsule filling machines is known to present many problems to their operators. Such problems are caused by relatively complicated requirements on rheological properties of capsule fillings which vary with the filling technique used as those techniques rely on different physical principles. This review provides an overview of automated and semi-automated capsule-filling processes, emphasizing the aspects of processed particulate mixture behavior in the process; this description determines the process requirements on rheological properties of capsule fillings. Rheological properties which can be used to study and optimize the filling process are discussed, as well as methods of improving those properties using the flow additives.

Published

2020-07-15

How to Cite

Komínová, P., & Zámostný, P. (2020). Flow Properties of Powder Mixtures as Factors of Hard Gelatin Capsule Filling. Chemické Listy, 114(7), 446–453. Retrieved from http://blog.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3638

Issue

Section

Articles

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